Introduction: Ischemia/reperfusion (I/R) injury induces an inflammatory response and production of oxygen-derived reactive species which affect many organs including heart, brain, kidney and gastrointestinal tract. The aim of this study was to assess the hepatic damage induced by renal I/R injury. Materials and methods: Male Wistar rats were divided into three groups. Hyperlipidemia was induced by feeding the rats with cholesterol (500 mg/kg per oral) in hydrogenated ground nut oil (as a vehicle) for 4 weeks. At the end of the fourth week, renal I/R injury was induced by occlusion of both renal vascular pedicles for 60 minutes, followed by 24-hour reperfusion. At the end of the experiment, liver was isolated for biochemical analysis. Results: Hyperlipidemic I/R rats have significantly higher levels of lipid peroxidation, xanthine oxidase, nitric oxide and myeloperoxidase, and lower levels of antioxidant enzymes (reduced glutathione, superoxide dismutase and catalase) compared to hyperlipidemic group. Conclusion: This study elucidated the oxidative and inflammatory role of hepatic damage induced by renal I/R injury.
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